[HTML][HTML] Hepatocyte growth factor-induced scatter of Madin-Darby canine kidney cells requires phosphatidylinositol 3-kinase
Hepatocyte growth factor/scatter factor (HGF/SF) is a multifunctional cytokine that induces
mitogenesis, motility, invasion, and morphogenesis of several epithelial and endothelial cell
lines in culture. The receptor for HGF/SF has been identified as the Met tyrosine kinase. To
investigate the signaling pathways that are involved in these events, we have generated
chimeric receptors containing the extracellular domain of the colony-stimulating factor-1
(CSF-1) receptor fused to the transmembrane and intracellular domains of the Met receptor …
mitogenesis, motility, invasion, and morphogenesis of several epithelial and endothelial cell
lines in culture. The receptor for HGF/SF has been identified as the Met tyrosine kinase. To
investigate the signaling pathways that are involved in these events, we have generated
chimeric receptors containing the extracellular domain of the colony-stimulating factor-1
(CSF-1) receptor fused to the transmembrane and intracellular domains of the Met receptor …