[HTML][HTML] Interaction of Macrophage-stimulating Protein with Its Receptor: RESIDUES CRITICAL FOR β CHAIN BINDING AND EVIDENCE FOR INDEPENDENT α …
A Danilkovitch, M Miller, EJ Leonard - Journal of Biological Chemistry, 1999 - ASBMB
Macrophage-stimulating protein (MSP) and hepatocyte growth factor/scatter factor (HGF/SF)
are plasminogen-related growth and motility factors that interact with cell-surface protein
tyrosine kinase receptors. Each one is a heterodimeric protein comprising a disulfide-linked
α chain and a serine protease-like β chain. Despite structural similarities between MSP and
HGF, the primary receptor binding site is located on the α chain of HGF/SF but on the β chain
of MSP. To obtain insight into the structural basis for MSP β chain binding, β chain structure …
are plasminogen-related growth and motility factors that interact with cell-surface protein
tyrosine kinase receptors. Each one is a heterodimeric protein comprising a disulfide-linked
α chain and a serine protease-like β chain. Despite structural similarities between MSP and
HGF, the primary receptor binding site is located on the α chain of HGF/SF but on the β chain
of MSP. To obtain insight into the structural basis for MSP β chain binding, β chain structure …