[CITATION][C] Activation of molecular oxygen by flavins and flavoproteins.

V Massey - Journal of Biological Chemistry, 1994 - Elsevier
V Massey
Journal of Biological Chemistry, 1994Elsevier
Fl,, H,+ 0,+ Fl,,+ H, O,(Eq. 1) is essentially irreversible. In free solution the reaction is slow
because of spin inversion associated with the reaction of singlet reduced flavin with triplet 0,
and complex, as described below. With flavoproteins the reaction with 0, may be orders of
magnitude faster or slower, depending on the specific flavoprotein or the class of
flavoprotein to which it belongs. Clearly the reactivity of the reduced flavin with 0, is
modulated by the protein environment in which it is located, both in terms of rates and …
Fl,, H,+ 0,+ Fl,,+ H, O,(Eq. 1) is essentially irreversible. In free solution the reaction is slow because of spin inversion associated with the reaction of singlet reduced flavin with triplet 0, and complex, as described below. With flavoproteins the reaction with 0, may be orders of magnitude faster or slower, depending on the specific flavoprotein or the class of flavoprotein to which it belongs. Clearly the reactivity of the reduced flavin with 0, is modulated by the protein environment in which it is located, both in terms of rates and products of the reaction (see Ref. 1 for a more detailed review).
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