Induction of antiphospholipid autoantibodies by immunization with beta 2 glycoprotein I (apolipoprotein H).
AE Gharavi, LR Sammaritano, J Wen… - The Journal of clinical …, 1992 - Am Soc Clin Investig
AE Gharavi, LR Sammaritano, J Wen, KB Elkon
The Journal of clinical investigation, 1992•Am Soc Clin InvestigA subset of patients with systemic lupus erythematosus has autoantibodies to acidic
phospholipids. Since lipids are poor immunogens, the mechanism responsible for the
induction of these antibodies is unclear. Immunization of a normal rabbit and normal mice
with purified human beta 2-glycoprotein I (apolipoprotein H) resulted in the production of
high levels of two non-cross-reactive antibody populations, anti-apolipoprotein H, and
antiphospholipid. The antiphospholipid antibodies had binding specificities …
phospholipids. Since lipids are poor immunogens, the mechanism responsible for the
induction of these antibodies is unclear. Immunization of a normal rabbit and normal mice
with purified human beta 2-glycoprotein I (apolipoprotein H) resulted in the production of
high levels of two non-cross-reactive antibody populations, anti-apolipoprotein H, and
antiphospholipid. The antiphospholipid antibodies had binding specificities …
A subset of patients with systemic lupus erythematosus has autoantibodies to acidic phospholipids. Since lipids are poor immunogens, the mechanism responsible for the induction of these antibodies is unclear. Immunization of a normal rabbit and normal mice with purified human beta 2-glycoprotein I (apolipoprotein H) resulted in the production of high levels of two non-cross-reactive antibody populations, anti-apolipoprotein H, and antiphospholipid. The antiphospholipid antibodies had binding specificities indistinguishable from autoantibodies obtained from human and murine lupus. These findings suggest a novel mechanism for the induction of antiphospholipid autoantibodies.
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