Molecular mimicry between a viral peptide and a myelin oligodendrocyte glycoprotein peptide induces autoimmune demyelinating disease in mice
F Mokhtarian, Z Zhang, Y Shi, E Gonzales… - Journal of …, 1999 - Elsevier
Semliki Forest Virus (SFV) induces an encephalomyelitis followed by demyelination in the
brains of C57Bl6/J (B6) mice. To investigate the role of molecular mimicry in the
pathogenesis of postviral demyelination, alignment algorithms were used and amino acid
homologies between immunogenic epitopes of SFV and myelin autoantigens, myelin basic
protein (MBP), myelin proteolipid protein (PLP) and myelin oligodendrocyte glycoprotein
(MOG) were identified. Immunization of B6 mice with SFV proteins induced significant …
brains of C57Bl6/J (B6) mice. To investigate the role of molecular mimicry in the
pathogenesis of postviral demyelination, alignment algorithms were used and amino acid
homologies between immunogenic epitopes of SFV and myelin autoantigens, myelin basic
protein (MBP), myelin proteolipid protein (PLP) and myelin oligodendrocyte glycoprotein
(MOG) were identified. Immunization of B6 mice with SFV proteins induced significant …