Catastrophic antiphospholipid syndrome: clues to the pathogenesis from a series of 80 patients
RA Asherson, R Cervera, JC Piette, Y Shoenfeld… - Medicine, 2001 - journals.lww.com
The antiphospholipid syndrome (APS), originally defined as the combination of venous or
arterial thrombotic events, recurrent fetal loss, and, frequently, a moderate thrombocytopenia
in association with antiphospholipid antibodies (aPL), was subsequently greatly expanded
to include diverse conditions, for example, heart valve lesions, adrenal insufficiency, and
pulmonary syndromes such as acute respiratory distress syndrome (ARDS),“capillaritis,” and
pulmonary alveolar hemorrhage, among others (16, 17). It was then realized that several …
arterial thrombotic events, recurrent fetal loss, and, frequently, a moderate thrombocytopenia
in association with antiphospholipid antibodies (aPL), was subsequently greatly expanded
to include diverse conditions, for example, heart valve lesions, adrenal insufficiency, and
pulmonary syndromes such as acute respiratory distress syndrome (ARDS),“capillaritis,” and
pulmonary alveolar hemorrhage, among others (16, 17). It was then realized that several …