Proteasome inhibition: a novel mechanism to combat asthma
PJ Elliott, CS Pien, TA McCormack, ID Chapman… - Journal of allergy and …, 1999 - Elsevier
Background: Nuclear factor-κB (NF-κB) is a critical transcription factor required for the
regulation of many genes involved in inflammatory responses to noxious stimuli. On
activation, NF-κB induces the transcription of numerous proinflammatory cytokines,
enzymes, and cellular adhesion molecules. Blockade of the proteasome with selective
inhibitors attenuates the effects of NF-κB, leading to suppression of the inflammatory
response. Objective: We sought to determine whether proteasome inhibitors would be active …
regulation of many genes involved in inflammatory responses to noxious stimuli. On
activation, NF-κB induces the transcription of numerous proinflammatory cytokines,
enzymes, and cellular adhesion molecules. Blockade of the proteasome with selective
inhibitors attenuates the effects of NF-κB, leading to suppression of the inflammatory
response. Objective: We sought to determine whether proteasome inhibitors would be active …