Bystander suppression of experimental autoimmune encephalomyelitis by T cell lines and clones of the Th2 type induced by copolymer 1
R Aharoni, D Teitelbaum, M Sela, R Arnon - Journal of neuroimmunology, 1998 - Elsevier
The synthetic amino acid copolymer, copolymer 1 (Cop 1) induces T suppressor (Ts)
lines/clones, which are confined to the Th2 pathway, cross react with myelin basic protein
(MBP), but not with other myelin antigens on the level of Th2 cytokine secretion.
Nevertheless, Cop 1 Ts cells inhibited the IL-2 response of a proteolipid protein (PLP)
specific line. Furthermore, Cop 1 Ts cells ameliorated EAE induced by two unrelated
encephalitogenic epitopes of PLP: p139–151 and p178–191, that produced different forms …
lines/clones, which are confined to the Th2 pathway, cross react with myelin basic protein
(MBP), but not with other myelin antigens on the level of Th2 cytokine secretion.
Nevertheless, Cop 1 Ts cells inhibited the IL-2 response of a proteolipid protein (PLP)
specific line. Furthermore, Cop 1 Ts cells ameliorated EAE induced by two unrelated
encephalitogenic epitopes of PLP: p139–151 and p178–191, that produced different forms …