An obligate role for T-cell receptor αβ+ T cells but not T-cell receptor γδ+ T cells, B cells, or CD40/CD40L interactions in a mouse model of atopic dermatitis
AL Woodward, JM Spergel, H Alenius… - Journal of allergy and …, 2001 - Elsevier
Background: We recently described a murine model of atopic dermatitis (AD) elicited by
epicutaneous sensitization with ovalbumin (OVA). The skin lesions in these mice were
characterized by a dermal infiltrate consisting of eosinophils and T cells and by increased
expression of the TH2 cytokines IL-4 and IL-5. Epicutaneous sensitization induces a rise in
the levels of serum total IgE and OVA-specific antibodies, further indicating that it elicits a
predominantly TH2 response. Objective: This study was undertaken to assess the roles of T …
epicutaneous sensitization with ovalbumin (OVA). The skin lesions in these mice were
characterized by a dermal infiltrate consisting of eosinophils and T cells and by increased
expression of the TH2 cytokines IL-4 and IL-5. Epicutaneous sensitization induces a rise in
the levels of serum total IgE and OVA-specific antibodies, further indicating that it elicits a
predominantly TH2 response. Objective: This study was undertaken to assess the roles of T …