Platelet/endothelial cell adhesion molecule-1 (CD31)-mediated cellular aggregation involves cell surface glycosaminoglycans
Platelet/endothelial cell adhesion molecule-1 (PECAM-1, CD31) is a 130-kDa integral
membrane glycoprotein expressed on endothelial cells, platelets, and leukocytes.
Experiments analyzing the aggregation of mouse L-cells stably transfected with full-length
PECAM-1 cDNA have demonstrated that PECAM-1 is capable of mediating calcium-
dependent heterophilic aggregation. In this report the ligand interactions involved in the
aggregation process were studied. This aggregation was inhibited by heparin and …
membrane glycoprotein expressed on endothelial cells, platelets, and leukocytes.
Experiments analyzing the aggregation of mouse L-cells stably transfected with full-length
PECAM-1 cDNA have demonstrated that PECAM-1 is capable of mediating calcium-
dependent heterophilic aggregation. In this report the ligand interactions involved in the
aggregation process were studied. This aggregation was inhibited by heparin and …