[HTML][HTML] Extracellular cleavage of the vascular endothelial growth factor 189-amino acid form by urokinase is required for its mitogenic effect
J Plouët, F Moro, S Bertagnolli, N Coldeboeuf… - Journal of Biological …, 1997 - ASBMB
Alternative splicing of vascular endothelial growth factor (VEGF) mRNA results in three
distinct molecular forms of 121 or 165 (V165) amino acids that are released in the
conditioned medium of cultured cells and one longer isoform of 189 amino acids (V189) that
remains cell-associated. V189 has been expressed in wild type CHO-K1 cells and in
glycosaminoglycan-deficient pgsA-745 Chinese hamster ovary (CHO) mutant cells. It could
be released from CHO-K1 cell membranes by heparin or a synthetic peptide designed on …
distinct molecular forms of 121 or 165 (V165) amino acids that are released in the
conditioned medium of cultured cells and one longer isoform of 189 amino acids (V189) that
remains cell-associated. V189 has been expressed in wild type CHO-K1 cells and in
glycosaminoglycan-deficient pgsA-745 Chinese hamster ovary (CHO) mutant cells. It could
be released from CHO-K1 cell membranes by heparin or a synthetic peptide designed on …