Endothelial–perivascular cell signaling in vascular development: lessons from knockout mice
P Lindahl, M Hellström, M Kalén… - Current opinion in …, 1998 - journals.lww.com
P Lindahl, M Hellström, M Kalén, C Betsholtz
Current opinion in lipidology, 1998•journals.lww.comThe importance of perivascular–endothelial cell interactions during blood vessel
development is discussed in the light of recent findings in platelet‐derived growth factor‐B,
platelet‐derived growth factor receptor‐β, angiopoietin‐1 and tie‐2 knockout mice, which all
show deficient development of perivascular cells. The initial formation of networks of
endothelial tubes (vasculogenesis) does not seem to depend on the perivascular cells but
subsequent vessel remodeling relies on mesenchymal–endothelial short‐range signaling …
development is discussed in the light of recent findings in platelet‐derived growth factor‐B,
platelet‐derived growth factor receptor‐β, angiopoietin‐1 and tie‐2 knockout mice, which all
show deficient development of perivascular cells. The initial formation of networks of
endothelial tubes (vasculogenesis) does not seem to depend on the perivascular cells but
subsequent vessel remodeling relies on mesenchymal–endothelial short‐range signaling …
Abstract
The importance of perivascular–endothelial cell interactions during blood vessel development is discussed in the light of recent findings in platelet‐derived growth factor‐B, platelet‐derived growth factor receptor‐β, angiopoietin‐1 and tie‐2 knockout mice, which all show deficient development of perivascular cells. The initial formation of networks of endothelial tubes (vasculogenesis) does not seem to depend on the perivascular cells but subsequent vessel remodeling relies on mesenchymal–endothelial short‐range signaling. Based on findings in platelet‐derived growth factor and platelet‐derived growth factor receptor knockout mice, a general model for the role of platelet‐derived growth factors in smooth muscle development is proposed. Curr Opin Lipidol 9: 407–411.© 1998 Lippincott Williams & Wilkins
Lippincott Williams & Wilkins