[HTML][HTML] The Carboxyl-terminal Domain (111–165) of Vascular Endothelial Growth Factor Is Critical for Its Mitogenic Potency (∗)

BA Keyt, LT Berleau, HV Nguyen, H Chen… - Journal of Biological …, 1996 - ASBMB
Vascular endothelial growth factor (VEGF) is a potent and specific mitogen for endothelial
cells. VEGF is synthesized and secreted by many differentiated cells in response to a variety
of stimuli including hypoxia. VEGF is expressed in a variety of tissues as multiple
homodimeric forms (121, 165, 189, and 206 amino acids/monomer) resulting from
alternative RNA splicing. VEGF 121 is a soluble mitogen that does not bind heparin; the
longer forms of VEGF bind heparin with progressively higher affinity. The higher molecular …