Elevation of intracellular cyclic AMP induces an anergic-like state in Th1 clones
RE Cone, R Cochrane, EG Lingenheld, RB Clark - Cellular immunology, 1996 - Elsevier
Because elevated intracellular cAMP suppresses T cell receptor (TCR)-mediated effector
activity and/or proliferation in response to antigen but does not always affect IL-2-stimulated
proliferation, the effects of cAMP on a T lymphocyte response to antigen resemble antigen-
induced anergy. To test the hypothesis that elevated cAMP induces anergy in T
lymphocytes, we have precultured murine Th1 clones responsive to porcine myelin basic
protein (PMBP) with dibutyryl cyclic AMP (dbcAMP) or forskolin and subsequently removed …
activity and/or proliferation in response to antigen but does not always affect IL-2-stimulated
proliferation, the effects of cAMP on a T lymphocyte response to antigen resemble antigen-
induced anergy. To test the hypothesis that elevated cAMP induces anergy in T
lymphocytes, we have precultured murine Th1 clones responsive to porcine myelin basic
protein (PMBP) with dibutyryl cyclic AMP (dbcAMP) or forskolin and subsequently removed …