[PDF][PDF] Origin of the corneocyte lipid envelope (CLE): observations in harlequin ichthyosis and cultured human keratinocytes
PM Elias, M Fartasch, D Crumrine, M Behne… - The Journal of …, 2000 - core.ac.uk
PM Elias, M Fartasch, D Crumrine, M Behne, Y Uchida, WM Holleran
The Journal of investigative dermatology, 2000•core.ac.ukAs cells of the outer stratum granulosum (SG) transform into corneocytes, they generate a
rigid, chemically resistant,» 15 nm thick peripheral envelope, the cornified envelope
(CE)(Matoltsy, 1976; Steven and Steinert, 1994). CE formation begins with the deposition
initially of involucrin (Steinert and Marekov, 1997), followed by the subjacent, catalytic cross-
linking of several other peptide precursors (Steinert and Marekov, 1995, 1997), by the
keratinocyte-specific, Ca++ dependent enzyme, transglutaminase 1 (TG1)(Parenteau et al …
rigid, chemically resistant,» 15 nm thick peripheral envelope, the cornified envelope
(CE)(Matoltsy, 1976; Steven and Steinert, 1994). CE formation begins with the deposition
initially of involucrin (Steinert and Marekov, 1997), followed by the subjacent, catalytic cross-
linking of several other peptide precursors (Steinert and Marekov, 1995, 1997), by the
keratinocyte-specific, Ca++ dependent enzyme, transglutaminase 1 (TG1)(Parenteau et al …
As cells of the outer stratum granulosum (SG) transform into corneocytes, they generate a rigid, chemically resistant,» 15 nm thick peripheral envelope, the cornified envelope (CE)(Matoltsy, 1976; Steven and Steinert, 1994). CE formation begins with the deposition initially of involucrin (Steinert and Marekov, 1997), followed by the subjacent, catalytic cross-linking of several other peptide precursors (Steinert and Marekov, 1995, 1997), by the keratinocyte-specific, Ca++ dependent enzyme, transglutaminase 1 (TG1)(Parenteau et al, 1986; Michel and DeÂmarchez, 1988;
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