Uptake of heparin cofactor II and antithrombin into the aorta wall after a deendothelializing injury in vivo: comparison with the behaviors of prothrombin and fibrinogen
MWC Hatton, B Ross, SMR Southward… - Journal of Laboratory …, 1999 - Elsevier
The initiation of a denuding injury to the vascular endothelium rapidly leads to a deposition
of platelets and fibrin at the site of injury. We have measured previously the responses of
rabbit fibrinogen, prothrombin, and antithrombin to a deendothelializing balloon-catheter
injury to the rabbit aorta in vivo. In this study, rabbit iodine 125–labeled HCII and iodine 125–
labeled AT were coinjected intravenously into anesthetized rabbits 5 minutes before
deendothelialization of the thoracic aorta. The rabbit was exsanguinated at 5 to 60 minutes …
of platelets and fibrin at the site of injury. We have measured previously the responses of
rabbit fibrinogen, prothrombin, and antithrombin to a deendothelializing balloon-catheter
injury to the rabbit aorta in vivo. In this study, rabbit iodine 125–labeled HCII and iodine 125–
labeled AT were coinjected intravenously into anesthetized rabbits 5 minutes before
deendothelialization of the thoracic aorta. The rabbit was exsanguinated at 5 to 60 minutes …