CD45 modulates phosphorylation of both autophosphorylation and negative regulatory tyrosines of Lyn in B cells
S Yanagi, H Sugawara, M Kurosaki, H Sabe… - Journal of Biological …, 1996 - ASBMB
CD45 is a tyrosine phosphatase that is required for normal B cell receptor (BCR)-mediated
signaling. It has been shown that Src-family tyrosine kinases such as Lyn could be a
potential substrate for CD45. In vitro studies indicate that activities of Src family tyrosine
kinases are regulated by tyrosine phosphorylation; C-terminal phosphorylation is inhibitory,
and autophosphorylation is stimulatory. We report here that both autophosphorylation and C-
terminal negative regulatory tyrosines of Lyn were hyperphosphorylated in CD45-deficient …
signaling. It has been shown that Src-family tyrosine kinases such as Lyn could be a
potential substrate for CD45. In vitro studies indicate that activities of Src family tyrosine
kinases are regulated by tyrosine phosphorylation; C-terminal phosphorylation is inhibitory,
and autophosphorylation is stimulatory. We report here that both autophosphorylation and C-
terminal negative regulatory tyrosines of Lyn were hyperphosphorylated in CD45-deficient …
