Positive and negative regulation of Src-family membrane kinases by CD45
ML Thomas, EJ Brown - Immunology today, 1999 - cell.com
ML Thomas, EJ Brown
Immunology today, 1999•cell.comCD45 is a protein tyrosine phosphatase that functions to regulate Src-family kinases.
However, in some instances CD45 is a positive regulator of kinase activity whereas in
others, it is a negative regulator. Here, Matthew Thomas and Eric Brown discuss this
paradox and suggest a mechanism by which CD45 can be both a positive and negative
regulator of kinase activity simultaneously.
However, in some instances CD45 is a positive regulator of kinase activity whereas in
others, it is a negative regulator. Here, Matthew Thomas and Eric Brown discuss this
paradox and suggest a mechanism by which CD45 can be both a positive and negative
regulator of kinase activity simultaneously.
Abstract
CD45 is a protein tyrosine phosphatase that functions to regulate Src-family kinases. However, in some instances CD45 is a positive regulator of kinase activity whereas in others, it is a negative regulator. Here, Matthew Thomas and Eric Brown discuss this paradox and suggest a mechanism by which CD45 can be both a positive and negative regulator of kinase activity simultaneously.
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