Dissociated production of interleukin-2 and immune gamma-interferon by phytohaemoagglutinin stimulated peripheral mononuclear cells in type 1 (insulin-dependent …
C Giordano, C Caruso, F Panto, MA Modica… - Journal of Clinical & …, 1988 - europepmc.org
C Giordano, C Caruso, F Panto, MA Modica, AM Zambito, MP Amato, A Galluzzo
Journal of Clinical & Laboratory Immunology, 1988•europepmc.orgIn order to analyze the first steps of T cell activation in type 1 diabetes we studied in vitro IL-2
and gamma-IFN production by peripheral blood mononuclear cells after 24 h PHA
stimulation. There was a significant decrease in IL-2 production by mononuclear cells of the
diabetic patients with respect to the controls. No significant difference was observed
between the diabetic patients and the healthy subjects as regards gamma-IFN production.
These observations may be interesting in relation to the pathogenetic mechanisms involved …
and gamma-IFN production by peripheral blood mononuclear cells after 24 h PHA
stimulation. There was a significant decrease in IL-2 production by mononuclear cells of the
diabetic patients with respect to the controls. No significant difference was observed
between the diabetic patients and the healthy subjects as regards gamma-IFN production.
These observations may be interesting in relation to the pathogenetic mechanisms involved …
In order to analyze the first steps of T cell activation in type 1 diabetes we studied in vitro IL-2 and gamma-IFN production by peripheral blood mononuclear cells after 24 h PHA stimulation. There was a significant decrease in IL-2 production by mononuclear cells of the diabetic patients with respect to the controls. No significant difference was observed between the diabetic patients and the healthy subjects as regards gamma-IFN production. These observations may be interesting in relation to the pathogenetic mechanisms involved in type 1 diabetes. In particular, normal gamma-IFN production may indicate integrity of the natural killer circuit.
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