Noncanonical Vα24JαQ T cells with conservative α chain CDR3 region amino acid substitutions are restricted by CD1d
SC Kent, DA Hafler, JL Strominger, SB Wilson - Human immunology, 1999 - Elsevier
Human NKRP-1A (CD161)+ T cells include members of a family of CD4+ or CD4-/CD8-
lymphocytes that utilize an invariant α chain in the T-cell receptor (TCR). The α chain
consists of the Vα24 segment joined to Jα18 (JαQ)(TCRAV24/AJ18). These families of T
cells rapidly produce both interleukin-4 and interferon-γ upon TCR cross-linking, and are
restricted by CD1d. To determine the spectrum of allowable V/J rearrangements in the
Vα24+ CD4-/CD8-family, TCR Vα24 chain transcripts derived from the total CD4-/CD8 …
lymphocytes that utilize an invariant α chain in the T-cell receptor (TCR). The α chain
consists of the Vα24 segment joined to Jα18 (JαQ)(TCRAV24/AJ18). These families of T
cells rapidly produce both interleukin-4 and interferon-γ upon TCR cross-linking, and are
restricted by CD1d. To determine the spectrum of allowable V/J rearrangements in the
Vα24+ CD4-/CD8-family, TCR Vα24 chain transcripts derived from the total CD4-/CD8 …