[HTML][HTML] Apoptosis and activation of the sphingomyelin-ceramide pathway induced by oxidized low density lipoproteins are not causally related in ECV-304 …
I Escargueil-Blanc, N Andrieu-Abadie… - Journal of Biological …, 1998 - ASBMB
Oxidized low density lipoproteins (oxLDL) are thought to play a central role in the
development of atherosclerosis. Toxic concentrations of mildly oxidized LDL elicit massive
apoptosis of endothelial cells (Escargueil-Blanc, I., Meilhac, O., Pieraggi, MT, Arnal JF,
Salvayre, R., Nègre-Salvayre, A.(1997) Arterioscler. Thromb. Vasc. Biol. 17, 331–339). Since
the lipid mediator ceramide emerged as a potent inducer of apoptosis, we aimed at
investigating the occurrence of ceramide formation and its potential role in oxLDL-induced …
development of atherosclerosis. Toxic concentrations of mildly oxidized LDL elicit massive
apoptosis of endothelial cells (Escargueil-Blanc, I., Meilhac, O., Pieraggi, MT, Arnal JF,
Salvayre, R., Nègre-Salvayre, A.(1997) Arterioscler. Thromb. Vasc. Biol. 17, 331–339). Since
the lipid mediator ceramide emerged as a potent inducer of apoptosis, we aimed at
investigating the occurrence of ceramide formation and its potential role in oxLDL-induced …