A correlation between atherogenesis and lipoprotein oxidation was first suggested by
experiments showing increased uptake by macrophages of oxidized LDL and oxidized LDL
injury to cultured cells. Recent data which demonstrate the existence of oxidized lipoproteins
in vivo, combined with studies showing a 'protective'effect of antioxidants against
atherosclerosis progression, have greatly increased the interest in theories posing that
lipoprotein oxidation is causally related to arterial disease. The fact that dozens of new …