The other side of scavenger receptors: pattern recognition for host defense
M Krieger - Current opinion in lipidology, 1997 - journals.lww.com
M Krieger
Current opinion in lipidology, 1997•journals.lww.comScavenger receptors bind modified lipoproteins and may play an important role both in
normal and in pathological lipid metabolism. A number of different classes of scavenger
receptors have been identified and several of these are multiligand receptors. Studies, both
in vitro and in vivo, have indicated that at least some of these scavenger receptors may
serve as pattern recognition receptors because they are able to bind a wide variety of
pathogens. As a consequence, they may play key roles in innate immunity and host defense.
normal and in pathological lipid metabolism. A number of different classes of scavenger
receptors have been identified and several of these are multiligand receptors. Studies, both
in vitro and in vivo, have indicated that at least some of these scavenger receptors may
serve as pattern recognition receptors because they are able to bind a wide variety of
pathogens. As a consequence, they may play key roles in innate immunity and host defense.
Abstract
Scavenger receptors bind modified lipoproteins and may play an important role both in normal and in pathological lipid metabolism. A number of different classes of scavenger receptors have been identified and several of these are multiligand receptors. Studies, both in vitro and in vivo, have indicated that at least some of these scavenger receptors may serve as pattern recognition receptors because they are able to bind a wide variety of pathogens. As a consequence, they may play key roles in innate immunity and host defense.
Lippincott Williams & Wilkins