T-cell priming by type-1and type-2 polarized dendritic cells: the concept of a third signal
P Kaliński, CMU Hilkens, EA Wierenga… - Immunology today, 1999 - cell.com
P Kaliński, CMU Hilkens, EA Wierenga, ML Kapsenberg
Immunology today, 1999•cell.comPrimary immune responses are initiated by dendritic cells (DCs), which inform naive T
helper (Th) cells about invading pathogens, providing an antigen-specific 'signal 1'and a
costimulatory 'signal 2'. Considering recent findings that myeloid DCs developing and
maturing in different conditions are functionally different, Pawel Kaliński and colleagues
suggest that migrating DCs carry an additional 'signal 3', contributing to the initial
commitment of naive Th cells into Th1 or Th2 subsets.
helper (Th) cells about invading pathogens, providing an antigen-specific 'signal 1'and a
costimulatory 'signal 2'. Considering recent findings that myeloid DCs developing and
maturing in different conditions are functionally different, Pawel Kaliński and colleagues
suggest that migrating DCs carry an additional 'signal 3', contributing to the initial
commitment of naive Th cells into Th1 or Th2 subsets.
Abstract
Primary immune responses are initiated by dendritic cells (DCs), which inform naive T helper (Th) cells about invading pathogens, providing an antigen-specific ‘signal 1' and a costimulatory ‘signal 2'. Considering recent findings that myeloid DCs developing and maturing in different conditions are functionally different, Pawel Kaliński and colleagues suggest that migrating DCs carry an additional ‘signal 3', contributing to the initial commitment of naive Th cells into Th1 or Th2 subsets.
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