B7-1 and B7-2 do not deliver identical costimulatory signals, since B7-2 but not B7-1 preferentially costimulates the initial production of IL-4
GJ Freeman, VA Boussiotis, A Anumanthan… - Immunity, 1995 - cell.com
GJ Freeman, VA Boussiotis, A Anumanthan, GM Bernstein, XY Ke, PD Rennert, GS Gray…
Immunity, 1995•cell.comThe functional necessity for two CD28 counterrecep ton,(87-l and 87-2) is presently
unknown. 87-l and 87-2 equivalently costimulate IL-2 and interferon-y (IFNy) production and
IL-2 receptor a and 1 chain expression. 87-2 Induces significantly more IL-4 production than
87-1, with the greatest difference seen In nalve T cells. Repetitive costlmulation of CD4+
CD48RA+ T cells with 87-2 results in moderate levels of both IL-4 and IL-2, whereas
repetitive costimulation wlth 87-l results in high levels of IL-2 and low levels of IL-4 …
unknown. 87-l and 87-2 equivalently costimulate IL-2 and interferon-y (IFNy) production and
IL-2 receptor a and 1 chain expression. 87-2 Induces significantly more IL-4 production than
87-1, with the greatest difference seen In nalve T cells. Repetitive costlmulation of CD4+
CD48RA+ T cells with 87-2 results in moderate levels of both IL-4 and IL-2, whereas
repetitive costimulation wlth 87-l results in high levels of IL-2 and low levels of IL-4 …
Summary
The functional necessity for two CD28 counterrecep ton,(87-l and 87-2) is presently unknown. 87-l and 87-2 equivalently costimulate IL-2 and interferon-y (IFNy) production and IL-2 receptor a and 1 chain expression. 87-2 Induces significantly more IL-4 production than 87-1, with the greatest difference seen In nalve T cells. Repetitive costlmulation of CD4+ CD48RA+ T cells with 87-2 results in moderate levels of both IL-4 and IL-2, whereas repetitive costimulation wlth 87-l results in high levels of IL-2 and low levels of IL-4. Therefore, 87-l and 87-2 costimulation mediate dlstinct outcomes, since 87-2 provides an Initial signal to induce naive T cells to become IL-4 producers, thereby directing the Immune response more towards ThOl Th2, whereas 87-l is a more neutral differentlative signal.
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