[HTML][HTML] Differential use of very late antigen-4 and-5 integrins by hematopoietic precursors and myeloma cells to adhere to transforming growth factor-β1-treated bone …
MM Robledo, F Sanz-Rodriguez, A Hidalgo… - Journal of Biological …, 1998 - ASBMB
The very late antigen (VLA)-4 and VLA-5 integrins mediate hematopoietic progenitor cell
attachment to bone marrow (BM) stroma. Transforming growth factor-β1 (TGF-β1) is a
cytokine present in the BM microenvironment that has been shown to regulate the synthesis
of adhesion elements in several cell types. We have investigated whether TGF-β1 action on
human BM stromal cells affected the adhesion of progenitor cells involving integrins VLA-4
and VLA-5. Two precursor cell lines, pre-B Nalm-6 and the multipotential UT-7, attached to …
attachment to bone marrow (BM) stroma. Transforming growth factor-β1 (TGF-β1) is a
cytokine present in the BM microenvironment that has been shown to regulate the synthesis
of adhesion elements in several cell types. We have investigated whether TGF-β1 action on
human BM stromal cells affected the adhesion of progenitor cells involving integrins VLA-4
and VLA-5. Two precursor cell lines, pre-B Nalm-6 and the multipotential UT-7, attached to …