[HTML][HTML] SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130

J Schmitz, M Weissenbach, S Haan, PC Heinrich… - Journal of Biological …, 2000 - ASBMB
Interleukin-6 is involved in the regulation of many biological activities such as gene
expression, cell proliferation, and differentiation. The control of the termination of cytokine
signaling is as important as the regulation of initiation of signal transduction pathways. Three
families of proteins involved in the down-regulation of cytokine signaling have been
described recently:(i) SH2 domain-containing protein-tyrosine phosphatases (SHP),(ii)
suppressors of cytokine signaling (SOCS), and (iii) protein inhibitors of activated STATs …