[HTML][HTML] A common pro-opiomelanocortin-binding element mediates leukemia inhibitory factor and corticotropin-releasing hormone transcriptional synergy
C Bousquet, DW Ray, S Melmed - Journal of Biological Chemistry, 1997 - ASBMB
Using murine AtT20 pituitary cells transfected with a rat pro-opiomelanocortin (POMC)
promoter (− 706/+ 64) linked to the luciferase reporter, we showed leukemia inhibitory factor
(LIF) to strongly potentiate corticotropin-releasing hormone (CRH) induction of POMC gene
expression. We therefore tested mechanisms for molecular interactions between LIF and
CRH. Although LIF and CRH synergized to induce an 8-fold induction of POMC
transcription, CRH alone (but not LIF) induced cAMP response element-binding protein …
promoter (− 706/+ 64) linked to the luciferase reporter, we showed leukemia inhibitory factor
(LIF) to strongly potentiate corticotropin-releasing hormone (CRH) induction of POMC gene
expression. We therefore tested mechanisms for molecular interactions between LIF and
CRH. Although LIF and CRH synergized to induce an 8-fold induction of POMC
transcription, CRH alone (but not LIF) induced cAMP response element-binding protein …