The cap-to-tail guide to mRNA turnover
CJ Wilusz, M Wormington, SW Peltz - Nature reviews Molecular cell …, 2001 - nature.com
CJ Wilusz, M Wormington, SW Peltz
Nature reviews Molecular cell biology, 2001•nature.comThe levels of cellular messenger RNA transcripts can be regulated by controlling the rate at
which the mRNA decays. Because decay rates affect the expression of specific genes, they
provide a cell with flexibility in effecting rapid change. Moreover, many clinically relevant
mRNAs—including several encoding cytokines, growth factors and proto-oncogenes—are
regulated by differential RNA stability. But what are the sequence elements and factors that
control the half-lives of mRNAs?
which the mRNA decays. Because decay rates affect the expression of specific genes, they
provide a cell with flexibility in effecting rapid change. Moreover, many clinically relevant
mRNAs—including several encoding cytokines, growth factors and proto-oncogenes—are
regulated by differential RNA stability. But what are the sequence elements and factors that
control the half-lives of mRNAs?
Abstract
The levels of cellular messenger RNA transcripts can be regulated by controlling the rate at which the mRNA decays. Because decay rates affect the expression of specific genes, they provide a cell with flexibility in effecting rapid change. Moreover, many clinically relevant mRNAs — including several encoding cytokines, growth factors and proto-oncogenes — are regulated by differential RNA stability. But what are the sequence elements and factors that control the half-lives of mRNAs?
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