[HTML][HTML] Differential activation of protein kinase B and p70S6K by glucose and insulin-like growth factor 1 in pancreatic β-cells (INS-1)
LM Dickson, MK Lingohr, J McCuaig, SR Hügl… - Journal of Biological …, 2001 - ASBMB
It has been shown that IGF-1-induced pancreatic β-cell proliferation is glucose-dependent;
however, the mechanisms responsible for this glucose dependence are not known.
Adenoviral mediated expression of constitutively active phosphatidylinositol 3-kinase (PI3K)
in the pancreatic β-cells, INS-1, suggested that PI3K was not necessary for glucose-induced
β-cell proliferation but was required for IGF-1-induced mitogenesis. Examination of the
signaling components downstream of PI3K, 3-phosphoinositide-dependent kinase 1, protein …
however, the mechanisms responsible for this glucose dependence are not known.
Adenoviral mediated expression of constitutively active phosphatidylinositol 3-kinase (PI3K)
in the pancreatic β-cells, INS-1, suggested that PI3K was not necessary for glucose-induced
β-cell proliferation but was required for IGF-1-induced mitogenesis. Examination of the
signaling components downstream of PI3K, 3-phosphoinositide-dependent kinase 1, protein …