The membrane-associated guanylate kinase protein MAGI-1 binds megalin and is present in glomerular podocytes
KM Patrie, AJ Drescher, M Goyal… - Journal of the …, 2001 - journals.lww.com
The transmembrane endocytic receptor glycoprotein 330/megalin (hereafter referred to as
megalin) is localized to the apical membrane domain of epithelial cells, where it is involved
in the uptake of proteins from extracellular sources. The cytoplasmic domain of megalin
contains amino acid motifs that have the potential to bind to other proteins, which may
influence its localization or function. The yeast two-hybrid system was used to search for
proteins that bind to the cytoplasmic tail of megalin, and a protein fragment from a mouse …
megalin) is localized to the apical membrane domain of epithelial cells, where it is involved
in the uptake of proteins from extracellular sources. The cytoplasmic domain of megalin
contains amino acid motifs that have the potential to bind to other proteins, which may
influence its localization or function. The yeast two-hybrid system was used to search for
proteins that bind to the cytoplasmic tail of megalin, and a protein fragment from a mouse …