Glomerular expression of dystroglycans is reduced in minimal change nephrosis but not in focal segmental glomerulosclerosis
HM Regele, E Fillipovic, B Langer… - Journal of the …, 2000 - journals.lww.com
Extensive flattening of podocyte foot processes and increased permeability of the glomerular
capillary filter are the major pathologic features of minimal change nephrosis (MCN) and
focal segmental glomerulosclerosis (FSGS). Adhesion proteins anchor and stabilize
podocytes on the glomerular basement membrane (GBM), and presumably are involved in
the pathogenesis of foot process flattening. Thus far, α 3 β 1-integrin was localized to basal
cell membrane domains. In this report, α-and β-dystroglycan (DG) were detected at precisely …
capillary filter are the major pathologic features of minimal change nephrosis (MCN) and
focal segmental glomerulosclerosis (FSGS). Adhesion proteins anchor and stabilize
podocytes on the glomerular basement membrane (GBM), and presumably are involved in
the pathogenesis of foot process flattening. Thus far, α 3 β 1-integrin was localized to basal
cell membrane domains. In this report, α-and β-dystroglycan (DG) were detected at precisely …