Life and death of the pancreatic β cells
S Bonner-Weir - Trends in Endocrinology & Metabolism, 2000 - cell.com
Trends in Endocrinology & Metabolism, 2000•cell.com
Pancreatic β cells are responsible for maintaining the body's glucose levels within a very
narrow range; their population is dynamic, with compensatory changes to maintain
euglycemia. Throughout the lifetime of a mammal, low levels of β-cell replication and
apoptosis are balanced and result in a slowly increasing mass of β cells. The emphasis in
this review is on recent insights on the natural history of the β cell in a normal pancreas:
sources of renewal, survival and changes in differentiation.
narrow range; their population is dynamic, with compensatory changes to maintain
euglycemia. Throughout the lifetime of a mammal, low levels of β-cell replication and
apoptosis are balanced and result in a slowly increasing mass of β cells. The emphasis in
this review is on recent insights on the natural history of the β cell in a normal pancreas:
sources of renewal, survival and changes in differentiation.
Abstract
Pancreatic β cells are responsible for maintaining the body's glucose levels within a very narrow range; their population is dynamic, with compensatory changes to maintain euglycemia. Throughout the lifetime of a mammal, low levels of β-cell replication and apoptosis are balanced and result in a slowly increasing mass of β cells. The emphasis in this review is on recent insights on the natural history of the β cell in a normal pancreas: sources of renewal, survival and changes in differentiation.
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