[HTML][HTML] Targeted down-regulation of caveolin-3 is sufficient to inhibit myotube formation in differentiating C2C12 myoblasts: transient activation of p38 mitogen …

F Galbiati, D Volonté, JA Engelman, PE Scherer… - Journal of Biological …, 1999 - ASBMB
Caveolin-3 is the principal structural protein of caveolae membrane domains in striated
muscle cells. Caveolin-3 mRNA and protein expression are dramatically induced during the
differentiation of C2C12 skeletal myoblasts, coincident with myoblast fusion. In these
myotubes, caveolin-3 localizes to the sarcolemma (muscle cell plasma membrane), where it
associates with the dystrophin-glycoprotein complex. However, it remains unknown what
role caveolin-3 plays in myoblast differentiation and myotube formation. Here, we employ an …