[HTML][HTML] Recombinant expression of caveolin-1 in oncogenically transformed cells abrogates anchorage-independent growth
JA Engelman, CC Wykoff, S Yasuhara, KS Song… - Journal of Biological …, 1997 - ASBMB
Caveolae are plasma membrane-attached vesicular organelles. Caveolin-1, a 21–24-kDa
integral membrane protein, is a principal component of caveolae membranes in vivo. Both
caveolae and caveolin are most abundantly expressed in terminally differentiated cells:
adipocytes, endothelial cells, and muscle cells. Conversely, caveolin-1 mRNA and protein
expression are lost or reduced during cell transformation by activated oncogenes such as v-
abl and H-ras (G12V); caveolae are absent from these cell lines. However, its remains …
integral membrane protein, is a principal component of caveolae membranes in vivo. Both
caveolae and caveolin are most abundantly expressed in terminally differentiated cells:
adipocytes, endothelial cells, and muscle cells. Conversely, caveolin-1 mRNA and protein
expression are lost or reduced during cell transformation by activated oncogenes such as v-
abl and H-ras (G12V); caveolae are absent from these cell lines. However, its remains …