Human hepatitis virus X gene encodes a regulatory domain that represses transactivation of X protein.
S Murakami, JH Cheong, S Kaneko - Journal of Biological Chemistry, 1994 - ASBMB
The human hepatitis B virus (HBV) X gene seems to be essential for establishment of viral
infection, and the X gene product, HBx, transactivates virus and host genes through a wide
variety of cis-elements, whereas regulation of HBx has not been fully understood. We found
that transactivation-negative HBx mutants truncated at the C-terminal portion specifically
repressed the HBx transactivation in trans. The ability to trans-repress the HBx
transactivation is confined to the N-terminal third of HBx. Transactivation-positive constructs …
infection, and the X gene product, HBx, transactivates virus and host genes through a wide
variety of cis-elements, whereas regulation of HBx has not been fully understood. We found
that transactivation-negative HBx mutants truncated at the C-terminal portion specifically
repressed the HBx transactivation in trans. The ability to trans-repress the HBx
transactivation is confined to the N-terminal third of HBx. Transactivation-positive constructs …