Current perspective on the role of apoptosis in atherothrombotic disease
Z Mallat, A Tedgui - Circulation research, 2001 - Am Heart Assoc
Z Mallat, A Tedgui
Circulation research, 2001•Am Heart AssocThrombus formation on a disrupted atherosclerotic plaque is a threatening event that leads
to vessel occlusion and acute ischemia. In this current perspective, we present evidence for
apoptosis as a major determinant of the thrombogenicity of the plaque lipid core and a
potential contributor to plaque erosion and associated thrombosis. Moreover, apoptosis may
directly affect blood thrombogenicity through the release of apoptotic cells and
microparticles into the bloodstream.
to vessel occlusion and acute ischemia. In this current perspective, we present evidence for
apoptosis as a major determinant of the thrombogenicity of the plaque lipid core and a
potential contributor to plaque erosion and associated thrombosis. Moreover, apoptosis may
directly affect blood thrombogenicity through the release of apoptotic cells and
microparticles into the bloodstream.
Abstract
—Thrombus formation on a disrupted atherosclerotic plaque is a threatening event that leads to vessel occlusion and acute ischemia. In this current perspective, we present evidence for apoptosis as a major determinant of the thrombogenicity of the plaque lipid core and a potential contributor to plaque erosion and associated thrombosis. Moreover, apoptosis may directly affect blood thrombogenicity through the release of apoptotic cells and microparticles into the bloodstream.
Am Heart Assoc