[HTML][HTML] Dominant-negative c-Jun NH2-terminal kinase 2 sensitizes renal inner medullary collecting duct cells to hypertonicity-induced lethality independent of organic …
PA Wojtaszek, LE Heasley, G Siriwardana… - Journal of Biological …, 1998 - ASBMB
The c-Jun NH 2-terminal protein kinases (JNKs), as well as the extracellular signal-
regulated protein kinases (ERKs) and p38 mitogen-activated protein kinase, are activated in
renal cells in response to extracellular hypertonicity. To determine whether activation of
JNKs by hypertonicity is isoform-specific, renal inner medullary collecting duct cells were
stably transfected with cDNA's encoding hemagglutinin (HA)-tagged JNK1 and JNK2
isoforms, and the expressed kinases were immunoprecipitated with an anti-HA antibody …
regulated protein kinases (ERKs) and p38 mitogen-activated protein kinase, are activated in
renal cells in response to extracellular hypertonicity. To determine whether activation of
JNKs by hypertonicity is isoform-specific, renal inner medullary collecting duct cells were
stably transfected with cDNA's encoding hemagglutinin (HA)-tagged JNK1 and JNK2
isoforms, and the expressed kinases were immunoprecipitated with an anti-HA antibody …