Cardiotrophin-1 (CT-1) was recently isolated by expression cloning based on its ability to
induce an increase in cell size in neonatal rat ventricular cardiomyocytes. Sequence
similarity data suggested that CT-1 is a novel member of a family of structurally related
cytokines sharing the receptor component gp130. The present study documents that gp130
is required for CT-1 signaling in cardiomyocytes, by demonstrating that a monoclonal anti-
gp130 antibody completely inhibits c-fos induction by CT-1. Similarly, a leukemia inhibitory …