[HTML][HTML] The suppressors of cytokine signaling (SOCS) proteins: important feedback inhibitors of cytokine action
NA Nicola, CJ Greenhalgh - Experimental hematology, 2000 - Elsevier
While positive effectors of cytokine signaling pathways are relatively well defined, negative
regulation can be just as important but is poorly understood. The recently discovered
suppressor of cytokine signaling (SOCS) family of proteins has been implicated in the
negative regulation of several cytokine pathways, particularly the receptor-associated
tyrosine kinase/signal transducer and activator of transcription (AK/STAT) pathways of
transcriptional activation. Biochemical studies revealed that inhibition can occur via a variety …
regulation can be just as important but is poorly understood. The recently discovered
suppressor of cytokine signaling (SOCS) family of proteins has been implicated in the
negative regulation of several cytokine pathways, particularly the receptor-associated
tyrosine kinase/signal transducer and activator of transcription (AK/STAT) pathways of
transcriptional activation. Biochemical studies revealed that inhibition can occur via a variety …