[HTML][HTML] Ligation of CD40 activates interleukin 1β-converting enzyme (caspase-1) activity in vascular smooth muscle and endothelial cells and promotes elaboration of …
U Schönbeck, F Mach, JY Bonnefoy… - Journal of Biological …, 1997 - ASBMB
Inflammation contributes to a variety of arterial diseases including atherosclerosis.
Interleukin 1β (IL-1β) in its activated mature 17-kDa form may mediate aspects of vascular
inflammation. As shown previously, human vascular wall cells, such as smooth muscle cells
(SMC), express the IL-1β precursor upon stimulation and the IL-1β-converting enzyme (ICE)
constitutively but do not produce mature IL-1β or express ICE activity. How SMC, the most
numerous cell type in arteries, may release active IL-1β has therefore remained a perplexing …
Interleukin 1β (IL-1β) in its activated mature 17-kDa form may mediate aspects of vascular
inflammation. As shown previously, human vascular wall cells, such as smooth muscle cells
(SMC), express the IL-1β precursor upon stimulation and the IL-1β-converting enzyme (ICE)
constitutively but do not produce mature IL-1β or express ICE activity. How SMC, the most
numerous cell type in arteries, may release active IL-1β has therefore remained a perplexing …