[HTML][HTML] Negative regulation of the forkhead transcription factor FKHR by Akt
The FKHR gene was first identified from its disruption by the t (2; 13) chromosomal
translocation seen in the pediatric tumor alveolar rhabdomyosarcoma. It encodes for a
member of the forkhead family of transcription factors. Recently, a homolog of FKHR in the
nematode Caenorhabditis elegans was identified called DAF-16, which is a downstream
target of two Akt homologs in an insulin-related signaling pathway. We have examined the
possible role of Akt in the regulation of FKHR. We find that FKHR can bind in vitro to the …
translocation seen in the pediatric tumor alveolar rhabdomyosarcoma. It encodes for a
member of the forkhead family of transcription factors. Recently, a homolog of FKHR in the
nematode Caenorhabditis elegans was identified called DAF-16, which is a downstream
target of two Akt homologs in an insulin-related signaling pathway. We have examined the
possible role of Akt in the regulation of FKHR. We find that FKHR can bind in vitro to the …