[HTML][HTML] Glucose metabolism to glucosamine is necessary for glucose stimulation of transforming growth factor-α gene transcription
PP Sayeski, JE Kudlow - Journal of Biological Chemistry, 1996 - ASBMB
Transforming growth factor-α (TGFα) gene transcription can be increased when arterial
smooth muscle cells are exposed to supraphysiological concentrations of glucose, and this
effect of glucose can be mimicked by glucosamine. To determine whether the metabolism of
glucose to glucosamine is required for this glucose effect, the rate-limiting step in glucose
metabolism to glucosamine through the enzyme glutamine: fructose-6-phosphate
amidotransferase (GFAT) was blocked using pharmacological and antisense strategies. We …
smooth muscle cells are exposed to supraphysiological concentrations of glucose, and this
effect of glucose can be mimicked by glucosamine. To determine whether the metabolism of
glucose to glucosamine is required for this glucose effect, the rate-limiting step in glucose
metabolism to glucosamine through the enzyme glutamine: fructose-6-phosphate
amidotransferase (GFAT) was blocked using pharmacological and antisense strategies. We …