Role of a guanine nucleotide-binding regulatory protein in the hydrolysis of hepatocyte phosphatidylinositol 4, 5-bisphosphate by calcium-mobilizing hormones and …
PF Blackmore, SB Bocckino, LE Waynick… - Journal of Biological …, 1985 - ASBMB
Treatment of isolated hepatocytes with NaF produced a concentration-dependent activation
of phosphorylase, inactivation of glycogen synthase, efflux of Ca2+, rise in cytosolic free
Ca2+ ([Ca2+] i), increase in myo-inositol-1, 4, 5,-P3 levels, decrease in phosphatidylinositol-
4, 5-P2 levels, and increase in 1, 2-diacylglycerol levels. These changes were evident within
1 min and maximum at 2-5 min. Maximum effects on Ca2+ efflux,[Ca2+] i, glycogen
synthase, and phosphorylase were observed with 15 mM NaF, whereas myo-inositol-1, 4, 5 …
of phosphorylase, inactivation of glycogen synthase, efflux of Ca2+, rise in cytosolic free
Ca2+ ([Ca2+] i), increase in myo-inositol-1, 4, 5,-P3 levels, decrease in phosphatidylinositol-
4, 5-P2 levels, and increase in 1, 2-diacylglycerol levels. These changes were evident within
1 min and maximum at 2-5 min. Maximum effects on Ca2+ efflux,[Ca2+] i, glycogen
synthase, and phosphorylase were observed with 15 mM NaF, whereas myo-inositol-1, 4, 5 …