Decreased food intake does not completely account for adiposity reduction after ob protein infusion.

N Levin, C Nelson, A Gurney… - Proceedings of the …, 1996 - National Acad Sciences
N Levin, C Nelson, A Gurney, R Vandlen, F De Sauvage
Proceedings of the National Academy of Sciences, 1996National Acad Sciences
The effects of recombinantly produced ob protein were compared to those of food restriction
in normal lean and genetically obese mice. Ob protein infusion into ob/ob mice resulted in
large decreases in body and fat-depot weight and food intake that persisted throughout the
study. Smaller decreases in body and fat-depot weights were observed in vehicle-treated
ob/ob mice that were fed the same amount of food as that consumed by ob protein-treated
ob/ob mice (pair feeding). In lean mice, ob protein infusion significantly decreased body and …
The effects of recombinantly produced ob protein were compared to those of food restriction in normal lean and genetically obese mice. Ob protein infusion into ob/ob mice resulted in large decreases in body and fat-depot weight and food intake that persisted throughout the study. Smaller decreases in body and fat-depot weights were observed in vehicle-treated ob/ob mice that were fed the same amount of food as that consumed by ob protein-treated ob/ob mice (pair feeding). In lean mice, ob protein infusion significantly decreased body and fat-depot weights, while decreasing food intake to a much lesser extent than in ob/ob mice. Pair feeding of lean vehicle-treated mice to the intake of ob protein-treated mice did not reduce body fat-depot weights. The potent weight-, adipose-, and appetite-reducing effects exerted by the ob protein in ob protein-deficient mice (ob/ob) confirm hypotheses generated from early parabiotic studies that suggested the existence of a circulating satiety factor of adipose origin. Pair-feeding studies provide compelling evidence that the ob protein exerts adipose-reducing effects in excess of those induced by reductions in food intake.
National Acad Sciences