Metformin
CJ Bailey, RC Turner - New England Journal of Medicine, 1996 - Mass Medical Soc
CJ Bailey, RC Turner
New England Journal of Medicine, 1996•Mass Medical SocMetformin (dimethylbiguanide) is an orally administered drug used to lower blood glucose
concentrations in patients with non-insulin-dependent diabetes mellitus (NIDDM). 1 It
improves insulin sensitivity and thus decreases the insulin resistance that is prevalent in
NIDDM. The efficacy of glycemic control achieved with metformin is similar to that achieved
with sulfonylureas, although their modes of action differ. Metformin can be used either as
initial therapy or as an additional drug when sulfonylurea therapy alone is inadequate. In …
concentrations in patients with non-insulin-dependent diabetes mellitus (NIDDM). 1 It
improves insulin sensitivity and thus decreases the insulin resistance that is prevalent in
NIDDM. The efficacy of glycemic control achieved with metformin is similar to that achieved
with sulfonylureas, although their modes of action differ. Metformin can be used either as
initial therapy or as an additional drug when sulfonylurea therapy alone is inadequate. In …
Metformin (dimethylbiguanide) is an orally administered drug used to lower blood glucose concentrations in patients with non-insulin-dependent diabetes mellitus (NIDDM).1 It improves insulin sensitivity and thus decreases the insulin resistance that is prevalent in NIDDM. The efficacy of glycemic control achieved with metformin is similar to that achieved with sulfonylureas, although their modes of action differ. Metformin can be used either as initial therapy or as an additional drug when sulfonylurea therapy alone is inadequate. In this article we shall discuss the pharmacology and clinical use of metformin, which is now available in the United States.
The Burden of Non-Insulin-Dependent . . .
The New England Journal Of Medicine