[HTML][HTML] Functional domains of the α1 catalytic subunit of the AMP-activated protein kinase
BE Crute, K Seefeld, J Gamble, BE Kemp… - Journal of Biological …, 1998 - ASBMB
The AMP-activated protein kinase is a heterotrimeric enzyme, important in cellular
adaptation to the stress of nutrient starvation, hypoxia, increased ATP utilization, or heat
shock. This mammalian enzyme is composed of a catalytic α subunit and noncatalytic β and
γ subunits and is a member of a larger protein kinase family that includes the SNF1 kinase of
Saccharomyces cerevisiae. In the present study, we have identified by truncation and site-
directed mutagenesis several functional domains of the α1 catalytic subunit, which modulate …
adaptation to the stress of nutrient starvation, hypoxia, increased ATP utilization, or heat
shock. This mammalian enzyme is composed of a catalytic α subunit and noncatalytic β and
γ subunits and is a member of a larger protein kinase family that includes the SNF1 kinase of
Saccharomyces cerevisiae. In the present study, we have identified by truncation and site-
directed mutagenesis several functional domains of the α1 catalytic subunit, which modulate …