Ultraviolet-irradiated apoptotic lymphocytes produce interleukin-10 by themselves
Y Tomimori, Y Ikawa, N Oyaizu - Immunology letters, 2000 - Elsevier
Since inflammatory responses are rarely associated with apoptotic cell death, it is plausible
that cells undergoing apoptosis may signal the immune system to suppress inflammatory
responses. By employing intracytoplasmic cytokine staining in conjunction with annexin V-
binding, we examined the representative pro-inflammatory cytokine tumor necrosis factor-α
(TNFα) and anti-inflammatory cytokine interleukin-10 (IL-10) expression in ultraviolet (UV)-
irradiated lymphocytes and analyzed them with apoptosis induction at a single cell level. We …
that cells undergoing apoptosis may signal the immune system to suppress inflammatory
responses. By employing intracytoplasmic cytokine staining in conjunction with annexin V-
binding, we examined the representative pro-inflammatory cytokine tumor necrosis factor-α
(TNFα) and anti-inflammatory cytokine interleukin-10 (IL-10) expression in ultraviolet (UV)-
irradiated lymphocytes and analyzed them with apoptosis induction at a single cell level. We …