Apoptosis: a basic biological phenomenon with wideranging implications in tissue kinetics
JFR Kerr, AH Wyllie, AR Currie - British journal of cancer, 1972 - nature.com
JFR Kerr, AH Wyllie, AR Currie
British journal of cancer, 1972•nature.comThe term apoptosis is proposed for a hitherto little recognized mechanism of controlled cell
deletion, which appears to play a complementary but opposite role to mitosis in the
regulation of animal cell populations. Its morphological features suggest that it is an active,
inherently programmed phenomenon, and it has been shown that it can be initiated or
inhibited by a variety of environmental stimuli, both physiological and pathological.
deletion, which appears to play a complementary but opposite role to mitosis in the
regulation of animal cell populations. Its morphological features suggest that it is an active,
inherently programmed phenomenon, and it has been shown that it can be initiated or
inhibited by a variety of environmental stimuli, both physiological and pathological.
Abstract
The term apoptosis is proposed for a hitherto little recognized mechanism of controlled cell deletion, which appears to play a complementary but opposite role to mitosis in the regulation of animal cell populations. Its morphological features suggest that it is an active, inherently programmed phenomenon, and it has been shown that it can be initiated or inhibited by a variety of environmental stimuli, both physiological and pathological.
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