[HTML][HTML] Receptor for advanced glycation end products (RAGE)-mediated neurite outgrowth and activation of NF-κB require the cytoplasmic domain of the receptor but …
HJ Huttunen, C Fages, H Rauvala - Journal of Biological Chemistry, 1999 - ASBMB
Receptor for advanced glycation end products (RAGE) mediates neurite outgrowth in vitro
on amphoterin-coated substrates. Ligation of RAGE by two other ligands, advanced
glycation end products or amyloid β-peptide, is suggested to play a role in cell injury
mechanisms involving cellular oxidant stress and activation of the transcription factor NF-κB.
However, the RAGE signaling pathways in neurite outgrowth and cell injury are largely
unknown. Here we show that transfection of RAGE to neuroblastoma cells induces …
on amphoterin-coated substrates. Ligation of RAGE by two other ligands, advanced
glycation end products or amyloid β-peptide, is suggested to play a role in cell injury
mechanisms involving cellular oxidant stress and activation of the transcription factor NF-κB.
However, the RAGE signaling pathways in neurite outgrowth and cell injury are largely
unknown. Here we show that transfection of RAGE to neuroblastoma cells induces …